DNA Insecticide: An Emerging Crop Protection Technology

Authors

  • Hemant Kumar Division of Entomology, ICAR- Indian Agricultural Research Institute, New Delhi 110012, Delhi
  • Sweta Verma Division of Entomology, ICAR- Indian Agricultural Research Institute, New Delhi 110012, Delhi
  • Rakesh Kumar Behera Division of Entomology, ICAR- Indian Agricultural Research Institute, New Delhi 110012, Delhi
  • Anamika Chandel Division of Vegetable Sciences, ICAR- Indian Agricultural Research Institute, New Delhi 110012, Delhi
  • Mohit Sharma Division of Genetics, ICAR- Indian Agricultural Research Institute, New Delhi 110012, Delhi
  • Doddachowdappa Sagar Division of Genomic Resources, ICAR-National Bureau of Agricultural Insect Resources, Bengaluru 560024, Karnataka

DOI:

https://doi.org/10.55446/IJE.2024.2160

Keywords:

Apoptosis, baculoviruses, coevolution, IAP genes, RING, DNA insecticide, oligonucleotide, rRNA, LdMNPV, RNAse-H, CUAD, 28 S RNA, olinside

Abstract

The agriculture industry faces a challenge in balancing the need for pest management and environmental protection. This review describes DNA insecticides, composed of small, single-stranded oligonucleotides that are environment-friendly and target pests efficiently and specifically DNA insecticide stems from the discovery of coevolution between baculo viruses and insects, where the virus exploit inhibitors of apoptosis (IAPs) genes to stop insect-induced apoptosis. Historically, the journey started by targeting IAP genes. Butthis context has now changed as DNA insecticides work best by targeting ribosomal RNAs (rRNA) of insect pests, where the oligonucleotide from rRNAs or any gene can be artificially designed using Contact Unmodified Antisense DNA (CUAD) Biotechnology to against the host target genes. DNA insecticides being operative in nature got later uncovered by humans showcases a novel, advantageous, and secure approach to manage insect pests.

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Published

2024-10-07

How to Cite

Kumar, H., Verma, S., Behera, R. K., Chandel, A., Sharma, M., & Sagar, D. (2024). DNA Insecticide: An Emerging Crop Protection Technology. Indian Journal of Entomology. https://doi.org/10.55446/IJE.2024.2160

Issue

Online First

Section

Research Articles
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Scopus
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Europe PMC

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