Mirror Repeats in the intersex Gene of Drosophila melanogaster Meigen

Authors

  • Kavita Saini Department of Zoology, Baba Mastnath University, Asthal Bohar Rohtak 124021, Haryana
  • Namrata Dangi Department of Zoology, Baba Mastnath University, Asthal Bohar Rohtak 124021, Haryana
  • Vikash Bhardwaj Department of Zoology, Baba Mastnath University, Asthal Bohar Rohtak 124021, Haryana

DOI:

https://doi.org/10.55446/IJE.2022.979

Keywords:

Drosophila melanogaster, intersex gene, mirror repeats, DNA repeats, parallel complement, Drosophila spp., origin, evolution, function

Abstract

Genomes of many organisms, including both prokaryotes and eukaryotes, contain numerous repeat elements. Among these DNA repeats, mirror repeats have been studied rarely. Hence, this study on the mirror repeats within the intersex gene of Drosophila melanogaster, which reveal 11 mirror repeats. Out of these mirror repeats, ten mirror repeats are perfect, and six are within a single exon. The presence of mirror repeats within the intersex gene raises further questions concerning their origin, evolution, and biological function.

Downloads

Download data is not yet available.

Metrics

Metrics Loading ...

Downloads

Published

2023-01-03

How to Cite

Saini, K., Dangi, N., & Bhardwaj, V. (2023). Mirror Repeats in the <i>intersex</i> Gene of <i>Drosophila melanogaster</i> Meigen. Indian Journal of Entomology, 85(1), 40–45. https://doi.org/10.55446/IJE.2022.979

Issue

Volume 85, Issue 1, March 2023

Section

Research Articles
Crossref
Scopus
Google Scholar
Europe PMC

References

Acharyya M, Chatterjee R N. 2002. Genetic analysis of an intersex allele ( ix 5 ) that regulates sexual phenotype of both female and male Drosophila melanogaster. Genetical Research 80(1): 7-14.

Aquilina B, Cauchi R J. 2018. Modelling motor neuron disease in fruit flies: Lessons from spinal muscular atrophy. Journal of Neuroscience Methods 310: 3-11.

Arunkumar K P, Nagaraju J. 2011. Drosophila intersex orthologue in the silkworm, Bombyx mori and related species. Genetica 139(1): 141-147.

Baker B S. 1989. Sex in flies: the splice of life. Nature 340(6234): 521-524.

Biscotti M A, Olmo E, Heslop Harrison J S. 2015. Repetitive DNA in eukaryotic genomes. Chromosome Research 23(3): 415-420.

Britten R J, Kohne D E. 1968. Repeated Sequences in DNA: Hundreds of thousands of copies of DNA sequences have been incorporated into the genomes of higher organisms. Science 161(3841): 529-540.

Burtis K C, Baker B S. 1989. Drosophila doublesex gene controls somatic sexual differentiation by producing alternatively spliced mRNAs encoding related sex-specific polypeptides. Cell 56(6): 997-1010.

Cavaliere D, Di Cara F, Polito, Lino C, Digilio F A. 2009. Cloning and functional characterization of the intersex homologous gene in the pest lepidopteron Maruca vitrata. The International Journal of Developmental Biology 53(7): 1057-1062.

Christiansen A E, Keisman E L, Ahmad S M, Baker B S. 2002. Sex comes in from the cold: the integration of sex and pattern. Trends in Genetics 18(10): 510-516.

Evangelakou Z, Manola M, Gumeni S, Trougakos I P. 2019. Nutrigenomics as a tool to study the impact of diet on aging and age-related diseases: the Drosophila approach. Genes & Nutrition 14(1): 1-12.

Garrett Engele C M, Siegal M L, Manoli D S, Williams B C, Li H, Baker B S. 2002a. intersex , a gene required for female sexual development in Drosophila , is expressed in both sexes and functions together with doublesex to regulate terminal differentiation. Development 129(20): 4661-4675.

Gurusaran M, Ravella D, Sekar K. 2013. RepEx: Repeat extractor for biological sequences. Genomics 102(4): 403-408.

Hartl D L, Nurminsky D I, Jones R W, Lozovskaya E R. 1994. Genome structure and evolution in Drosophila: applications of the framework P1 map. Proc. Natl. Acad. Sci. U.S.A. 91(15): 6824-6829.

Jurka J, Kapitonov V V, Kohany O, Jurka M V. 2007. Repetitive Sequences in Complex Genomes: Structure and Evolution. Annu. Rev. Genom. Hum. Genet 8(1): 241-259.

Kapitonov V, Jurka J. 2003. Molecular paleontology of transposable elements in the Drosophila melanogaster genome. Proc. Natl. Acad. Sci. U.S.A. 100(11): 6569-6574.

Kaufman T C, 2017. A Short History and Description of Drosophila melanogaster Classical Genetics: Chromosome Aberrations, Forward Genetic Screens, and the Nature of Mutations. Genetics 206(2): 665-689.

Mirzoyan Z, Sollazzo M, Allocca M, Valenza A M, Grifoni D, Bellosta P. 2019. Drosophila melanogaster: A Model Organism to Study Cancer. Frontiers in Genetics 10: 51.

Pandey U B, Nichols C D. 2011. Human Disease Models in Drosophila melanogaster and the Role of the Fly in Therapeutic Drug Discovery. Pharmacol Rev 63(2): 411-436.

Peng Q, Chen J, Pan Y. 2021. From fruitless to sex: On the generation and diversification of an innate behavior. Genes, Brain and Behavior 20(8).

Reiter L T, Potocki L, Chien S, Gribskov M, Bier E. 2001. A Systematic Analysis of Human Disease-Associated Gene Sequences In Drosophila melanogaster. Genome Research. 11(6): 1114-1125.

Tolwinski N. 2017. Introduction: Drosophila - A Model System for Developmental Biology. JDB 5(3): 9.

Treangen T J, Salzberg S L. 2012. Repetitive DNA and next-generation sequencing: computational challenges and solutions. Nat Rev Genet 13(1): 36-46.

Volfovsky N, Haas B J, Salzberg S L. 2001. A clustering method for repeat analysis in DNA sequences. Genome Biol 2(8): 1-11.

Wangler M F, Yamamoto S, Bellen H J. 2015. Fruit Flies in Biomedical Research. Genetics 199(3): 639-653.