Harnessing Wolbachia to Reduce Dengue Transmission - a Review
DOI:
https://doi.org/10.55446/IJE.2024.1527Keywords:
Aedes aegypti, dengue, Wolbachia-infected mosquitoes, Wolbachia deployment, DENV reduction, cytoplasmic incompatibility, insect-specific viruses, pelo protein, Toll pathway, mathematical modelling.Abstract
In this article, we discuss the possible, underlying molecular and biological basis of dengue case reduction by Wolbachia-infected mosquitoes, their field releases trial, and mathematical modelling of reduction in transmission of DENV attributable to the presence of Wolbachia. This study suggests that Wolbachia-infected DENV control could reduce dengue incidences up to 40.3 to 96% in the field release sites and A laboratory-based trial reported 100% suppression when Wolbachia-infected male mosquitoes were released. Moreover, Mathematical modeling predicted promising results in dengue reduction by Wolbachia. Documented evidence in this study support Wolbachia as a novel vector control approach to limit dengue transmission.
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