Harnessing Wolbachia to Reduce Dengue Transmission - a Review


  • Smita Bordoloi Department of Life Sciences, Dibrugarh University, Dibrugarh 786004, Assam
  • Siraj Ahmed Khan Division of Medical Entomology, Arbovirology and Rickettsial Diseases, ICMR-RMRC NE Region, Dibrugarh 786010
  • Pramit Ghosh Division of Medical Entomology, Arbovirology and Rickettsial Diseases, ICMR-RMRC NE Region, Dibrugarh 786010
  • Devid Kardong Department of Life Sciences, Dibrugarh University, Dibrugarh 786004, Assam




Aedes aegypti, dengue, Wolbachia-infected mosquitoes, Wolbachia deployment, DENV reduction, cytoplasmic incompatibility, insect-specific viruses, pelo protein, Toll pathway, mathematical modelling.


In this article, we discuss the possible, underlying molecular and biological basis of dengue case reduction by Wolbachia-infected mosquitoes, their field releases trial, and mathematical modelling of reduction in transmission of DENV attributable to the presence of Wolbachia. This study suggests that Wolbachia-infected DENV control could reduce dengue incidences up to 40.3 to 96% in the field release sites and A laboratory-based trial reported 100% suppression when Wolbachia-infected male mosquitoes were released. Moreover, Mathematical modeling predicted promising results in dengue reduction by Wolbachia. Documented evidence in this study support Wolbachia as a novel vector control approach to limit dengue transmission.


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How to Cite

Bordoloi, S., Khan, S. A., Ghosh, P., & Kardong, D. (2024). Harnessing <i>Wolbachia</i> to Reduce Dengue Transmission - a Review. Indian Journal of Entomology, 1–11. https://doi.org/10.55446/IJE.2024.1527



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